Anti- Human CD3 Monoclonal Ant ibody (OKT3)
Product Description:
The product is a monoclonal antibody against human CD3 molecule which expressed on mature T cell. In mammals, CD3 combines with TCR and CD247 molecules to form TCR-CD3 complex and then mediates T cell activation. CD3 molecule is composed of one γ chain, one δ chain and two ε chains, and is responsible for the singnaling transduction for T cell activation. Therefore, T cells also can be directly induced into actiavation and proliferation by antibodies (such as O KT3 ) targeted CD3 molecule.The target epitope recognized by OKT3 is the ε chain of CD3. O KT3 reacts with all peripheral T cells and CD3+ thymocytes in human. This product is s uitable for the activation and expansion of T lymphocytes.
Application:
Special design for the activation and expansion of cultured human T cells.
Storage:
Keep at - 20 to - 70 ℃ in lyophilized form.
After dissolution, it shall be s ub-packed and stored at - 20 to - 70 ℃. Avoid repeated freezing and thawing.
Specification:
High quality protein, 1mg/vial, white lyophilized powder.
Dosage instructions for use：
Diluted with PBS or sterile water. It is recommended for T cell activation in vitro at concentration of 100ng / ml, and suggets that each laboratory optimize its concentration for culture.
Shelf life:
Store under specified conditions for 24 months.
The diluted CD3 solution can be stored at 2-8 ℃ for one month.
