The product is a monoclonal antibody against human CD3 molecule which expressed on mature T cell. In mammals, CD3 combines with TCR and CD247 molecules to form TCR-CD3 complex and then mediates T cell activation. CD3 molecule is composed of one γ chain, one δ chain and two ε chains, and is responsible for the singnaling transduction for T cell activation. Therefore, T cells also can be directly induced into actiavation and proliferation by antibodies (such as OKT3) targeted CD3 molecule.The target epitope recognized by OKT3 is the ε chain of CD3. OKT3 reacts with all peripheral T cells and CD3+ thymocytes in human. This product is suitable for the activation and expansion of T lymphocytes.
Special design for the activation and expansion of cultured human T cells. High quality protein, 1mg/vial, white lyophilized powder.
No need to add serum during the culture.
Support robust CIK cells expansion for 14 days or 21 days in culture with flask or bag.
Expanded CIK cells exhibit strong cytotoxicity against tumor cells.
Storage: Keep at - 20 to - 70 °C in lyophilized form.
After dissolution, it shall be sub-packed and stored at - 20 to - 70 °C.
Avoid repeated freezing and thawing.
