Anti-Human CD3 Monoclonal Antibody (OKT3)

The product is a monoclonal antibody against human CD3 molecule which expressed on mature T cell. In mammals, CD3 combines with TCR and CD247 molecules to form TCR-CD3 complex and then mediates T cell activation. CD3 molecule is composed of one γ chain, one δ chain and two ε chains, and is responsible for the singnaling transduction for T cell activation. Therefore, T cells also can be directly induced into actiavation and proliferation by antibodies (such as OKT3) targeted CD3 molecule.The target epitope recognized by OKT3 is the ε chain of CD3. OKT3 reacts with all peripheral T cells and CD3+ thymocytes in human. This product is suitable for the activation and expansion of T lymphocytes.

Application / utility

Special design for the activation and expansion of cultured human T cells. 

High quality protein, 1mg/vial, white lyophilized powder.

Feature

• No need to add serum during the culture.
• Support robust CIK cells  expansion for 14  days or 21  days  in culture with flask or bag.
• Expanded CIK cells  exhibit strong cytotoxicity against tumor cells.

Storage

• Storage: Keep at - 20 to - 70 °C in lyophilized form.
• After dissolution, it shall be sub-packed and stored at - 20 to - 70 °C.
• Avoid repeated freezing and thawing.

Datasheet